M-Boltz Hackathon
Welcome to the M-Boltz Hack! This is the submission portal for the two binding challenges: Antibody–Antigen Binding and Allosteric–Orthosteric Ligand Binding.
Please use the respective tabs to submit your results and view the leaderboard for each challenge. Once you are ready to make your final submission, please use the 'Final Submission' tab. If you have any questions or issues, don't hesistate to open a Discussion in the Community tab.
Antibody-Antigen Binding Challenge
The goal of this challenge is to improve Boltz-2 accuracy for predicting the correct poses of a Fv/Fab region binding to an antigen.
Accuracy will be measured through the Capri-Q docking assessment classification scores and the final winner will be determined based on the number of successful top-1 predictions on our internal test set. However, you are encouraged to submit results on the training set during the hack to see where you stack up.
A prediction is deemed successful if the Capri-Q classification is either "high", "medium", or "acceptable". If multiple entries reach the same number of successful predictions, ties are broken by looking at the number of predictions with "High" classification, then with "Medium" classification and finally with "Acceptable" classification. If there is still a tie then, we will look at the mean RMSD across all successful predictions.
Submissions (Antibody–Antigen)
test | 1 | 2 | 3 | 4 |
Allosteric-Orthosteric Ligand Binding Challenge
The goal of this challenge is to improve Boltz-2 accuracy for predicting the binding poses of either allosteric or orthosteric ligands.
The winner will be determined by accuracy measured on our internal test set by calculating the RMSD between the top-1 prediction and the experimental pose. However, submit your intermediate results here to see where you stack up!
Submissions (Ligand Binding)
test | 3 | 6 | 9 | 10 | 11 |